华西第二医院

简介

1.职称：研究员

2.学历：博士

3.研究方向：调控心脏发育的新作用因子及其分子作用机制；生心祖细胞的新亚群及其分子标记的分离；心脏谱系细胞体外定向分化方法的探索与优化。

4.邮件：xuez@scu.edu.cn

5.个人经历：

2014.3—2017.7.1博士后，美国麻省理工学院

2014.3—2017.8  2009.1—2014.2博士，美国德克萨斯西南医学中心—达拉斯分校

6.代表性论文：

(1)Xue, Z., Ye, Q., Anson, S.R., Yang, J., Xiao, G., Kowbel, D., Glass, N.L., Crosthwaite, S.K., and Liu, Y. (2014). Transcriptional interference by antisense RNA is required for circadian clock function. Nature 514, 650-653. (IF=38.1)

(2)Xue, Z., Hennelly, S., Doyle, B., Gulati, A.A., Novikova, I.V., Sanbonmatsu, K.Y., and Boyer, L.A. (2016). A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage. Mol Cell 64, 37-50. (Highlighted by Mol Cell, Nature Chemical Biology, and Science Signaling) (IF=14.0)

(3)Xue, Z., Yuan, H., Guo, J., and Liu, Y. (2012). Reconstitution of an Argonaute-dependent small RNA biogenesis pathway reveals a handover mechanism involving the RNA exosome and the exonuclease QIP. Mol Cell 46, 299-310. (IF=14.0)

(4)Lee, H.C.*, Li, L.*, Gu, W.*, Xue, Z., Crosthwaite, S.K., Pertsemlidis, A., Lewis, Z.A., Freitag, M., Selker, E.U., Mello, C.C., Liu, Y. (2010). Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi. Mol Cell 38, 803-814. (IF=14.0)

(5)Zhang, Z.*, Chang, S.S.*, Zhang, Z., Xue, Z., Zhang, H., Li, S., and Liu, Y. (2013). Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway. Genes Dev 27, 145-150. (IF=10.0)

(6)Yang, Q., Li, L., Xue, Z., Ye, Q., Zhang, L., Li, S., and Liu, Y. (2013). Transcription of the major Neurospora crassa microRNA-like small RNAs relies on RNA polymerase III. PLoS Genet 9, e1003227. (IF=6.7)

(7)Dang, Y., Li, L., Guo, W., Xue, Z., and Liu, Y. (2013). Convergent transcription induces dynamic DNA methylation at disiRNA loci. PLoS Genet 9, e1003761. (IF=6.7)

(8)Dang, Y., Yang, Q., Xue, Z., and Liu, Y. (2011). RNA interference in fungi: pathways, functions, and applications. Eukaryot Cell 10, 1148-1155. (IF=3.4)