职称：教授

学历：博士

研究方向：

1. 早期胚胎发育尤其是细胞全能性建立与第一次细胞命运决定的表观遗传调控机制

2. 利用体细胞核移植与诱导多能干细胞技术研究体细胞重编程的分子机制

3. 利用病人诱导多能干细胞进行疾病发生机制及干细胞转化医学研究

邮箱：gaoshaorong@tongji.edu.cn

个人简历：

2013年-今，同济大学医学与生命科学部主任，教育部“细胞干性与命运编辑”前沿科学中心主任

2005年至2013年，北京生命科学研究所任研究员、高级研究员

2004年至2005年，美国康涅狄格州大学，研究助理教授

2002年至2004年，美国坦普尔大学医学院进行博士后研究

2000年至2002年，英国罗斯林研究所进行博士后研究，师从“克隆羊之父”伊恩威尔穆特教授

1998年至2000年，美国布朗大学医学院，研究助理

2000年，中国科学院动物研究所，博士学位

1996年，中国农业大学，硕士学位

1993年，山东农业大学，学士学位

中国科学院院士，中国医学科学院学术咨询委员会学部委员，教育部“细胞干性与命运编辑”前沿科学中心主任、国家杰出青年科学基金获得者、国家级人才、基金委创新群体学术带头人和国家重点研发计划首席科学家等称号。高绍荣教授坚持面向人民健康问题展开科学研究，聚焦胚胎发育与细胞重编程的表观调控机制这一世界前沿，不断探索基础研究与成果转化的发展模式，取得了一系列创新性研究成果。以第一完成人获国家自然科学奖二等奖（2020）和教育部自然科学奖一等奖（2019），以通讯作者（含共同）在Nature、Science（2篇）、Nature Cell Biology（3篇）、Cell Stem Cell（8篇）等国际权威学术期刊上发表论文170余篇，他引七千余次，并担任国际权威期刊Cell Stem Cell顾问委员会委员等多个国际知名学术期刊编委。

代表性论文(* 通讯作者)：

(1) Ma Q, Xu W, Wang X, Nie H, Gao Y, Hu R, Yang Z, Wang X, Na T, Chen X, Wang Z, Xu M, Shao L, Guo M, Liu Y, Le R, Gao S*, Li W*. (2026) Zinc accumulation-induced integrated stress response triggers β-cell identity loss. Cell Research Jan 28. doi: 10.1038/s41422-026-01222-y. Online ahead of print.

(2) Xiang Y, Qian Y, Li Z, Wang J, Tian R, Meng W, Bu J, Huang F, Ai Z, Wu D, Chen X, Wu Y, Shen L, Chan YS, Gao Y, Ma J, Liu W*, Gao S*, Zhang D*, Liang H*. (2026)Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development. Science 2026 Jan 22;391(6783):eadv5257.

(3) Yang L*, Di A, Song L, Liu X, Wu D, Wang S, Hao Z, Bu L, Bai C, Su G, Wei Z, Zhang L, Liu Z, Gao S*, Li G*. (2025) Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells. Nature Biotechnology Oct 7. doi: 10.1038/s41587-025-02832-4. Online ahead of print.

(4) Liu K, Yan Z, Bai D, Jiang R, Bi Y, Ma X, Xiang J, Sheng Y, Dong B, Ning Z, Yi S, Liu Y, Lei X, Jia Y, Zhang Y, Zhang Y, Li Y, Wu T, Xi C, Liu S, Liu S, Chen J, Yin J, Kou X, Zhao Y, Wang H, Wang Y, Wei K, Gao S*, Liu W*. (2025) Modeling post-gastrula development via bidirectional pluripotent stem cells. Cell Research 35(12):954-969. (Cover Story)

(5) Li Z, Qu S, Liang H, Tang R, Zhang X, Lu F, Yang J, Gan Z, Gao S*, Zhang Y*, Chen G*. (2025) Integrative deep learning of spatial multi-omics with SWITCH. Nature Computational Science 5(11):1051-1063.

(6) Li Y, He J, Liu Y, Hui Y, Liu S, Zhang Y, Xiong Y, Xu T, Xu Z, Zhang Z, Zhang Y, Yang G, Zhao J, Bai D, Lei X, Kou X, Zhao Y, Du J, Guo Z, Yin J, Zhang X, Xu C, Gao Y, Chen M, Wang H, Jiang C*, Gao S*, Liu W*. (2025) Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis. Nature Cell Biology 27(10):1797-1811.

(7) Zhu X, Chang Z, Xiao W, Zhang X, Ma M, Wu J, Hu J, Bi Y, Kou X, Zhao Y, Sheng Y, Dong B, Sun J, Chen C, Wu Y, Liu X, Ding W, Jia K, Yao Y, Sun L, Yu X, Wang H, Liu J*, Wang Y*, Gao S*, Gao Y*. (2025) N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells. Cell Stem Cell 32(11):1773-1791.

(8) Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y, Liu W*, Gao S*. (2023) Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm. Protein Cell 14(4):262-278. (Cover Story)

(9) Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui X, Zhang L, Zhao X, Liu Q, He P, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He Y, Li X, Gao S*, Gao Y*, He C*. (2022) FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development. Science 376(6596):968-973.

(10) Xu R, Li S, Wu Q, Li C, Jiang M, Guo L, Chen M, Yang L, Dong X, Wang H, Wang C*, Liu X*, Ou X*, Gao S*. (2022)Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos. Cell Stem Cell 29(7):1051-1066. (Cover Story; Previewed by Cell Stem Cell)

(11) Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B*, Gao Y*, Gao S*. (2022) N⁶-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during maternal-to-zygotic transition. Nature Cell Biology 24(6):917-927.

(12) Yang H, Bai D, Li Y, Yu Z, Wang C, Sheng Y, Liu W*, Gao S*, Zhang Y*. (2022) Allele-specific H3K9me3 and DNA methylation marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryos. Nature Cell Biology 24(5):783-792.

(13) Wang C, Chen C, Liu X, Li C, Wu Q, Chen X, Yang L, Kou X, Zhao Y, Wang H, Gao Y*, Zhang Y*, Gao S*. (2022) Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation. Cell Research 32(9):801-813. (Cover Story)

(14) Le R*, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, Li Z, Guo M, Kou X, Zhao Y, Chen M, Zhu Q, Zhao A, Yin J, Sun J, Su Z, Shi K, Gao Y, Chen J, Liu W, Kang L, Wang Y, Li C, Liu X, Gao R, Wang H, Ju Z*, Gao S*. (2021) Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells. Cell Stem Cell 28(4):732-747.

(15) Yang G, Zhang L, Liu W, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S*, Chen J*, Jiang C*. (2021) Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Cell Stem Cell 28(1):150-163.

(16) Chen C, Liu W, Guo J, Liu Y, Liu X, Liu J, Dou X, Le R, Huang Y, Li C, Yang L, Kou X, Zhao Y, Wu Y, Chen J, Wang H, Shen B*, Gao Y*, Gao S*. (2021) Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos. Protein Cell 12(6):455-474. (Cover Story)

(17) Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S*, Zhu B*. (2012) Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337(6097):971-5. (Previewed by Science)

(18) Kang L, Wang J, Zhang Y, Kou Z, Gao S*. (2009) iPS cells can support full term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2):135-138. (Highlighted by Nature, Nature China; Selected as “Must Read” by Faculty 1000; Featured in TIME Magazine, Washington Post, Wall Street Journal, Xinhua News, USA Today, The Scientist, The Economist, ABC News, The Independent, Scientific America etc.)