1.职称：主任医师

2.学历：博士

3.联系电话：028-88570018

4.电子邮箱：niuxy@scu.edu.cn

5.研究方向：妇科盆底、妇科泌尿、妇科肿瘤

6.简历

牛晓宇，主任医师，博士生导师，四川省科协海智特聘专家、四川省学术和技术带头人、四川省卫生厅学术技术带头人、四川省第十四届人大代表。现任中华医学会泌尿外科学分会女性学组副组长、中华预防医学会盆底功能障碍防治专业委员会常务委员、亚太结直肠联合会亚洲结直肠盆底疾病联盟常务副主席、中国整形美容协会女性生殖整复分会常务理事等学术职务。作为执行主编创办我国首本聚焦盆底疾病的国际期刊《Gynecology and Pelvic Medicine》，被ESCI收录；担任《Chinese Medical Journal》审稿人及《实用妇产科杂志》编委。现任四川大学华西第二医院副院长。1998年毕业于华西医科大学，获医学硕士学位，1998年毕业于四川大学，获医学博士学位。于2007年赴加拿大McGill University做博士后研究，2009年学成归国。随后深耕于医学事业。作为课题负责人承担了国家重点研发计划主动健康和老龄化科技应对重点专项、国家自然科学基金面上项目、四川省科技厅重点研发项目、四川省自然科学基金项目、四川省卫生健康委员会重点研发项目、四川省科技厅应用基础研究项目等。研究成果覆盖女性盆底疾病发病机制、精准诊断、健康管理及基层医疗体系建设等方面。发表论文80余篇，主编及参编专著14部，发布专家共识8篇、团体标准18项，荣获国家级奖励6项，获发明专利授权6项、实用新型专利授权5项、软件著作权7项，获医疗器械注册证2项，另有3项处受理阶段。带领团队参加国际会议，展示26项研究成果，引起国际同行广泛关注，提升了我国在盆底泌尿领域的国际话语权。建立西南盆底疾病专病联盟,102家单位加入。作为学科带头人，带领盆底医学中心获评妇女盆底功能障碍性疾病国家级及省级质量控制中心。盆底医学中心年手术超1000例，康复患者4万余例。建成国内首个融合泌尿、生殖、肛肠三大专科的国家级盆底医学中心，创建国家级盆底医师、技师、护理全序列人员规培基地。牵头创立国内首个跨学科盆底疾病诊治信息一体化平台，开展疾病预警、早诊、网格化管理等工作，有力推动了全省盆底医学学科建设及基层人才培养。培养硕士、博士研究生20余名。

7.承担项目情况

（1）国家自然科学基金面上项目，82571879，阴道干细胞样成纤维细胞在盆腔器官脱垂组织修复中的作用及调控机制研究，2026-2029。

（2）四川省自然科学基金项目，2026NSFSCZY0044，基于单细胞多组学解析成纤维细胞主导的间质-上皮互作在女性生殖道发育障碍中的作用机制研究，2026-2028。

（3）四川省科技厅重点研发项目，2023YFS0024，多模态盆底功能障碍性疾病智能检测仪研发，2023-2024。

（4）国家重点研发计划主动健康和老龄化科技应对重点专项，2021YFC2009100，老年女性盆底功能障碍的评估与干预技术研究，2021-2024。

（5）四川省卫生健康委员会重点研发项目，21ZD002，女性盆底功能障碍性疾病早期预警体系构建与示范应用研究，2021-2024。

8.代表性论文

（1）Zuoxi He, Qian Wang, Lisha Ding, Yisi Wang, Hongcheng He, Wuyue Han, Siyao Li, Jing Fu, Can Luo, Jingyu Li, Rui Gao, Yueyue Chen, Ling Mei, Dongmei Wei, Jian Meng, Yueting Zhang, Tao Wang, Xiaoyu Niu*, Segmental specification of the human female fetal reproductive tract revealed by spatiotemporal dynamics. Nature Cell Biology, 2026.

（2）Ling Mei, Dongmei Wei, Meiqin Zhang, Fengyuan Zou, Xiaoyu Niu*, Three-dimensional pelvic floor ultrasound measuring levator ani hiatus area and its association with pelvic organ prolapse: a population based retrospective cross-sectional study in Chinese women. Quant Imaging Med Surg. 2026.16(3):213.

（3）Can Luo, Xiaoyu Niu*, A comprehensive review of conservative therapies for female stress urinary incontinence: Advancements, efficacy, and future directions. Current Urology. 2025.19(2):84–89.

（4）Ling Mei, Linbo Gao, Tao Wang, Dong Yang, Weixing Chen, Xiaoyu Niu*. Development and Validation of Risk Assessment Model for Pelvic Organ Prolapse Based on A Retrospective Study with Machine Learning Algorithms. International Urogynecology Journal. 2025.36(8):1591-1599.

（5）Siyao Li, Yueyue Chen, Ling Mei, Xiaoyu Niu*, Long-Term Outcomes of Transvaginal Mesh in Younger Women: A Retrospective Study. International Urogynecology Journal.2025.12.

（6）Shuqin Zeng, Alexandre Almeida, Shiping Li, Junjie Ying, Hua Wang, Yi Qu, R Paul Ross, Catherine Stanton, Zhemin Zhou, Xiaoyu Niu*, Dezhi Mu*, Shaopu Wang. A metagenomic catalog of the early-life human gut virome. Nature Communications.2024.15:1864.

（7）Hao Bai, Yuqing Liu, Linbo Gao, Tao Wang, Xiaoli Zhang, Jie Hu, Lisha Ding, Yueting Zhang, Qian Wang, Lei Wang, Jianlong Li, Zhifeng Zhang, Yang Wang, Chenlan Shen, Binwu Ying, Xiaoyu Niu*, Wenchuang Hu*. A portable all-in-one microfluidic device with real-time colorimetric LAMP for HPV16 and HPV18 DNA point-of-care testing. Biosensors and Bioelectronics .2023.248(2024)115968.

（8）Mingxuan Fan, Xiaoling Peng, Xiaoyu Niu*, Tao Cui*, Qiaolin He,Missing data imputation, prediction, and feature selection in diagnosis of vaginal prolapse. BMC MEDICAL RESEARCH METHODOLOGY. 2023.23(2023):259.

（9）Qian Hu, Dan Tang, Mei Li, Xiaodu Liang, Juan zhou, Yanming Meng, Yinhao Wei, Shixin Yan, Ruoyu Lin, Xiaoyu Niu*, Lin Zhang*, Hybrid chain reaction and selective recognition-based homogeneous dual-fluorescence analysis of circulating tumor cells in clinical ovarian cancer samples. ANAL CHIM ACTA. 2023.Nov;1281.

（10）Ling Mei, Jian Meng, Dongmei Wei, Qian Hu, Yueyue Chen, Tao Cui, Yueting Zhang, Qiao Li, Xiaoli Zhang, Yuqing Liu, Qian Wang, Lisha Ding, Tao Wang, Yukuan Feng, Wei Lei, Yanhui Deng; Xiaoyun Gong, Jingchun Ling, Xiaoyu Niu*, Diagnostic test of bioimpedance-based neural network algorithm in early cervical cancer.Ann Transl Med.2022.10(8):471.

（11）Ling Mei, Tao Wang, Yueyue Chen, Dongmei Wei, Yueting Zhang, Tao Cui, Jian Meng, Xiaoli Zhang, Yuqing Liu, Lisha Ding, Xiaoyu Niu*, Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection, J Transl Med, 2022.20(1):12.

（12）Tao Wang, Yuqing Liu, Ling Mei, Tao Cui, Dongmei Wei, Yueyue Chen, Xiaoli Zhang, Linbo Gao, Shihong Zhang, Lanfang Guo, Pei Yang, Xiaoyu Niu*, Proteins in plasma as a potential biomarkers diagnostic for pelvic organ prolapse, Ann Transl Med, 2021.9(14): 1117.

（13）Hang Fu, Na Zhang, Yongli Zheng, Nan Jiang, Huayan Xu, Rong Xu, Linjun Xie, Zhongqin Zhou, Bin Kang, Tao Li, Jun Lin, Bennan ZhaoMS, Tao Zeng, Keke Hou, Xiaoyu Niu*, Yingkun Guo*, Risk stratification of cardiac sequelae detected using cardiac magnetic resonance In late convalescence at the six-month follow-up of recovered COVID-19 patients, Journal of Infection, 2021.83(1): 119-145.

（14）Dongmei Wei, Jian Meng, Qiao Li, Yajing Wang, Yueyue Chen, Xiaoyu Niu*, Efficacy and Safety of Laser Treatment in Vulvar Lichen Sclerosus: A Systematic Review. Lasers in Surgery and Medicine. 2025.8:1-11.

（15）Y Yu, L Mei, Y Chen, T Cui, D Wei*, X Niu*, Comparison of laparoscopic lateral suspension and high uterosacral ligament suspension for apical prolapse: a retrospective clinical study. Techniques in Coloproctology. 2025.29(1):84.

（16）Qian Wang, Zuoxi He, Lisha Ding, Yuqing Liu, Xiaoli Zhang, Tao Wang*, Xiaoyu Niu*, Comprehensive analysis of the circRNA ex-x-pression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse. Frontiers in Genetics. 2025.20(15):1527223.

（17）Dongmei Wei ,Yaoming Chen,Yueyue Chen,Tao Cui,Xiaoyu Niu*, Assessing the treatment effect of cranberry type A proanthocyanidins on vulvovaginal candidiasis: a randomised controlled clinical interventional study. Gynecology and Obstetrics Clinical Medicine.2024.2024(4)e000014.

（18）Ling Mei, Dongmei Wei, Yueyue Chen, Yueting Zhang, Tao Cui, Jian Meng, Xiaoli Zhang, Yuqing Liu, Lisha Ding, Qian Wang, Tao Wang, Xiaoyu Niu*, Vaginal Microbiota Changes in the Vulvar Lichen Simplex Chronicus. CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY. 2023.50(1):17.

（19）Yuqing Liu, Ling Mei, Yueyue Chen, Xiaoli Zhang, Dongmei Wei, Tao Cui, Yueting Zhang, Tao Wang, Xiaoyu Niu*, Association Between Potentially Functional Variants in chr5q14 and the Risk of Cervical Cancer in a Chinese Population. REPROD SCI.2022.

（20）Ling Mei, Heng Zhang, Yueyue Chen, Xiaoyu Niu*, Clinical features of congenital complete vaginal atresia combined with cervical aplasia: A retrospective study of 19 patients and litera ture review, Congenital Anomalies. 2021.61:127-132.