1.职称：研究员

2.学历：博士

3.研究方向：曹中炜为国家杰出青年（2021），国家优秀青年（2017）,国家级青年人才，四川大学华西第二医院／生物治疗国家重点实验室研究员。研究方向为血管微环境对肿瘤及器官纤维化的影响。以第一作者和通讯作者（含共同第一和共同通讯）在Nature, Cell, Nature Cell Biology, Nature Medicine, Cancer Cell, Science Translational Medicine,发表多篇论文。发表论文被Cell, Cancer Cell, Nature Reviews Drug Discovery, Nature Reviews Cancer, Science Signaling, Science Translational Medicine, Faulty of 1000网站专文介绍或评为“亮点”文章特别推荐。

4.邮件：zhongweicao@hotmail.com

5.教育经历：南京大学学士，硕士，加州大学戴维斯分校博士，斯坦福大学，康奈尔大学博士后，讲师

6.代表性论文

1) Yan Hu#, Biao Yang #, Chengju Xiao #, Xinchun Yang #,Hua Zhang #,Pengbo Yang #, Xiao Du #, Guixiang Zhang #,Beibei Liang #,Nan Bai #,Daoguang Zhang #,Dongbo Wu #,Qinghua Luo #,Yangjing Teng #, Yumeng Chen , Zhiqing Guo , Chengjian Zhao , Tinghong Ye , Dong Chai, Xiaolong Qi , Weiting Zhong, Jie Chen, Haohao Dong, Jinhang Gao, Huanhuan He, Junlei Chang, Xuri Li, Liang Peng, Shahin Rafii, Scott L Friedman , Cheng Yi, Yun Cai , Yanping Zhao , Hongjun Wang , Chen Wang , Zhongwei Cao , Bi-Sen Ding , Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis. Cell, 2026, 189:1-21. (* Correspondence)

2) Nan Yang#; Xiaoxue Li#; Wenwen Huang#; Gali Ji#; Wei Luo#; Hao Zeng; Yali Chen; Yao Chen; Lina Qiao; Lu Chen; Wei Wang*; Ai Zheng*; Bi-Sen Ding*; Zhongwei Cao*; MLKL PARylation in the endothelial niche triggers necroptosis to evade cancer immunosurveillance and chemotherapy, Nature Cell Biology, 2025, 17(2):123-136 (* Correspondence)

2） Hua Zhang#; Yongyuan Ma#; Xinying Cheng#; Dongbo Wu#; Xingming Huang#; Bin Chen; Yafeng Ren; Wei Jiang; Xiaoqiang Tang; Ting Bai; Yutian Chen; Yilin Zhao; Chunxue Zhang; Xia Xiao; Jing Liu; Yue Deng; Tinghong Ye; Lu Chen; Han-Min Liu; Scott L. Friedman; Liping Chen*; Bi-Sen Ding*; Zhongwei Cao*; Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis, Science Translational Medicine, 2021, 13(614): eabd1206  (* Correspondence)

3) Yutian Chen#; Qiang Pu#; Yongyuan Ma#; Hua Zhang#; Tinghong Ye#; Chengjian Zhao#; Xiaojuan. Huang; Yafeng Ren; Lina Qiao; Han-Min Liu; Charles T. Esmon; Bi-Sen Ding*; Zhongwei Cao*; Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis, Cell Metabolism, 2021, 33(2): 395-410.e4 (* Correspondence)

4) Bi-Sen Ding*; Dawei Yang; Steve L Swendeman; Christina Christoffersen; Lars B Nielsen; Scott L Friedman; Charles A Powell; Timothy Hla; Zhongwei Cao*; Aging suppresses sphingosine-1-phosphate (S1P) chaperone ApoM in circulation resulting in maladaptive organ repair, Developmental Cell, 2020, 53(6): 677-690.e4 (* Correspondence)

5) Zhongwei Cao*; Joseph M Scandura; Giorgio G Inghirami; Koji Shido; Bi-Sen Ding*; Shahin Rafii*; Molecular checkpoint decisions made by subverted vascular niche transform indolent tumor cells into chemoresistant cancer stem cells, Cancer Cell, 2017, 31(1): 110-126 (* Correspondence)

6) Zhongwei Cao*; Lis, Raphael; Ginsberg, Michael; Chavez, Deebly; Shido, Koji; Rabbany, Sina Y; Fong, Guo-Hua; Sakmar, Thomas P; Rafii, Shahin*; Ding, Bi-Sen*; Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis, Nature Medicine, 2016, 22(2): 154-162 (* Correspondence)

7) Chunheng Mo, Hui Li, Mengli Yan, Shiyu Xu, Jinyan Wu, Jiachen Li, Xinchun Yang, Yuanyuan Li, Jian Yang, Xingping Su, Jie Liu, Chuan Wu, Yuan Wang, Haohao Dong, Lu Chen, Lunzhi Dai, Ming Zhang*, Qiang Pu*, Liming Yang*, Tinghong Ye*, Zhongwei Cao*, Bi-Sen Ding*. Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis, Cell Metabolism, 2024;36(8):1839-1857 (* Correspondence)

8) Jie Ma, Liyin Zhang, Xu Zhang, Lanlan Zhang, Hua Zhang, Yulei Zhu, Xingming Huang, Ting Zhang, Xiangdong Tang, Yuan Wang, Lu Chen*, Qiang Pu*, Liming Yang*, Zhongwei Cao*, Bi-Sen Ding *. Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration, Science Translational Medicine, 2024 Aug 28;16(762):eado5266 (* Correspondence)

9）Jie Qing#; Yafeng Ren#; Yuwei Zhang; Mengli Yan; Hua Zhang; Dongbo Wu; Yongyuan Ma; Yutian Chen; Xiaojuan Huang; Qinkai Wu; Maryam Mazhar; Li Wang; Jian Liu; Bi-sen Ding*; Zhongwei Cao*; Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis, Journal of Hepatology, 2022, 76(2):394-406 (* Correspondence)

10) Zhongwei Cao*#; Tinghong Ye#; Yue Sun#; Gaili Ji#; Koji Shido; Yutian Chen; Lin Luo; Feifei Na; Xiaoyan Li; Zhen Huang; Jane L Ko; Vivek Mittal; Lina Qiao; Chong Chen; Fernando J Martinez; Shahin Rafii; Bi-Sen Ding*; Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis, Science Translational Medicine, 2017, 9(405): eaai8710 (* Correspondence)

11) Bi-Sen Ding#; Zhongwei Cao#; Raphael Lis; Daniel J. Nolan; Peipei Guo; Michael Simons; Mark E. Penfold; Koji Shido; Sina Y. Rabbany; Shahin Rafii*; Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis, Nature, 2014, 505(7481):97-102 (# equal contribution)

12) Zhongwei Cao; Bi-Sen Ding; Peipei Guo; Sharrell B Lee; Jason M Butler; Stephanie C Casey; Michael Simons; Wayne Tam; Dean W Felsher; Koji Shido; Arash Rafii; Joseph M Scandura; Shahin Rafii; Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance, Cancer Cell, 2014, 25(3):350-65