西部妇幼医学研究院 实验室介绍详细

跨膜转运与细胞代谢实验室Laboratory of Membrane Transport and Metabolism

负责人:邓东

PIDong Deng

本实验室主要致力于膜转运蛋白尤其是次级转运蛋白的转运机制研究,使用基于X-射线晶体学方法结合生物化学、生物物理等多学科研究方法,解析多个不同功能状态下的高分辨率转运蛋白结构;利用计算生物学方法对膜转运蛋白在转运过程中的的动态变化进行研究;脂类对转运蛋白的调节机制研究。

DengLabfocus on the research of the transport mechanisms of membrane transporters,especially secondary transporters, seeking to get high-resolution structures oftransporters in different states using X-ray crystallography combined withmultidisciplinary research tools involving biochemistry and biophysics. Besidesthe structure determination, we also aim to understand their dynamics bycomputational approach and the modulation of transporter by lipids.