西部妇幼医学研究院 实验室介绍详细

细胞内运输与相关疾病实验室Laboratory of Cellular Trafficking and Diseases

负责人:贾大

PI:Jia Da

贾大实验室研究领域为细胞内运输与相关疾病的分子机制,包括传染病,家族性精神疾病和免疫病在以往的工作中,我们在揭示家族性帕金森,免疫病Immunodeficiency,Centromeric instability and Facial anomalies(ICF)的细胞生物学和分子生物学机制等领域做出开创性的贡献。共发表论文12 篇,包括Nature(2篇), Cell,MolecularCell, PNAS等,被他人引用超过1500次。其中第一作者4 篇,包括Nature,PNAS等。 我们的文章被Cell,Nature, Nature Reviews Drug Discovery, Faculty of 1000文章或网站等评为亮点或者特别推荐文章(Editor’s choice).值得一提的是,我们的研究成果还被大众科技科普媒体包括中国《科技日报》,美国《Science Signaling》等报导。

The Jia Laboratory studies the mechanismsby which cellulartrafficking is regulated, with a focus on endosomal sorting. We are alsointerested in determininghow deregulation of cellular trafficking contributesto various diseases including infection, certain familial neurologicaldisorders, and immunodeficiency. Our past work has helped to illustrate thecellular and molecular mechanisms of familial Parkinson’s disease and HereditarySpastic ParaplegiaJia D.et al, PNAS, 2010;JiaD. et al, MBC, 2012;McGough I, Steinberg F, Jia D.et al, CurrentBiology,2014). Additionally, our landmark studies onDNA methylation lay foundation for the development of related anti-cancertherapy, and provide a molecular basis for Immunodeficiency, Centromeric instability and Facial anomalies, a rare immunologicaldisorder (Jia D.et al, Nature, 2007; Subramanian K., Jia D. et al, Molecular Cell,2008;OoiS. et al, Nature,2007).