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李征宇

副研究员,硕士生导师

2010年度教育部“新世纪优秀人才支持计划”获得者。2007年获四川大学产科专业博士学位,毕业后任职于四川大学华西第二医院产科,从事临床及科研工作。2009年破格晋升副研究员,并受聘为硕士研究生导师。
目前主要从事妇科恶性肿瘤蛋白质组学与基因治疗、肿瘤miRNA功能解析、生殖免疫关键因子解析等研究。博士学位论文获2009年“全国百篇优秀博士论文”。主持国家自然科学基金面上项目、青年基金项目、高等学校全国优博论文作者专项资金、四川大学优秀青年学者基金等多项课题。担任Human Gene Therapy,Arch Gynecol  Obstet等杂志特邀审稿人。目前在Mol Cell Proteomics (IF 9.425),Int J Cancer (IF 4.693),Human Gene Ther (IF 4.514)等杂志累计发表SCI收录文章十余篇,单篇影响因子最高为9.425。


主持的科研项目:
1. 国家自然科学基金面上项目:围着床期子宫内膜容受性形成过程中关键基因-miRNA-蛋白质级联调控机制解析,2012.1-2014.12,项目编号(81170592);
2. 高等学校全国优秀博士学位论文作者专项资金:免疫蛋白质组学鉴定妇科恶性肿瘤相关抗原分子及其功能鉴定,2010.1-2014.12,项目编号(201079);
3. 教育部新世纪优秀人才支持计划:人新基因PCIA1在母胎免疫耐受中调控作用的分子机制初探,2011.1月-2013.12,项目编号(NCET-10-0594);
4. 国家自然科学基金青年基金:Cyclophilin A基因作为潜在基因治疗靶点逆转子宫内膜癌化疗耐药作用及其分子机制研究,2010.1月-2012.12,项目编号(30901594);
5. 四川大学青年科学基金:针对cyclophilin A基因的miRNA抗肿瘤作用研究,2009.1-2010.10,项目编号(校青2008056)。
发表论文:
1,Li Zhengyu, Zhao Xia, Bai Shujun, Wang Zhi, Chen Lijuan, Wei Yuquan, Huang Canhua. Proteomic identification of cyclophilin A as a potential prognostic factor and therapeutic target in endometrial carcinoma. Mol Cell Proteomics 2008,7: 1810-1823
2, Li Zhengyu, Huang Canhua, Bai Shujun, Pan Xiaoling, Zhou Rong, Wei Yuquan, Zhao Xia. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach. Int J Cancer, 2008, 123:2377-2383.
3, Li Zhengyu, Wu Ying, Zhao Xia, Kan Bing, Wei Yuquan. Inhibition of ovarian tumor growth by gene therapy with recombinant soluble vascular endothelial growth factor receptor 2. Human Gene Therapy 2006, 17(9): 941-948.
4, Li Zhengyu, Yang Fan, Deng Hongxin, Yang Hanshuo, Yan Fei, Qian Zhiyong, Chen Lijuan, Wei Yuquan, Zhao Xia. Efficient inhibition of ovarian cancer growth and prolonged survival by transfection of a novel pro-apoptotic gene hPNAS-4 in vitro and in vivo mouse model. Oncology, 2008, 75:137-144.
5, Li Zhengyu, Liu Yi, Zhao Xia, Pan Xiaoling, Yin Rutie, Huang Canhua, Chen Lijuan, Wei Yuquan. Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells. Eur J Obstet Gynecol 2008, 140:95-102.
6, Li Zhengyu, Zhao Xia, Wei Yuquan. Regulation of apoptotic signal transduction pathway by the heat shock proteins. Science in China Series C 2004, 47(2): 107-114.
7, Li Zhengyu, Zhao Xia, Yang Jinliang, Wei Yuquan. Proteomics profile changes in cisplatin-treated human ovarian cancer cell strain. Science in China Series C 2005, 48(6): 648-657.
8, Li Zhengyu, Min Wenjiao, Huang Canhua, Bai Shujun, Tang Minghai, Zhao Xia. Proteomics-ba-x-sed approach identified differentially expressed proteins with potential roles in endometrial carcinoma. Int J Gynecol Cancer 2010, 20: 9-15.
9, Li Zhengyu, Sun Ying, Min Wenjiao, Zhang Dan. Correlation between overex-x-pression of transforming growth factor-beta 1 in occluded fallopian tubes and postsurgical pregnancy among infertile women. Int J Gynecol Obstet 2011, 112:11-14.
10, Zhi Wang, Lu Jiang, Canhua Huang, Zhengyu Li, Lijuan Chen, Lantu Gou, Ping Chen, Aiping Tong, Minghai Tang, Feng Gao, Jun Shen, Yuanyuan Zhang, Jingping Bai, Min Zhou, Di Miao, Qianming Chen. Comparative Proteomics Approach to Screening of Potential Diagnostic and Therapeutic Targets for Oral Squamous Cell Carcinoma. Mol Cell Proteomics 2008, 7:1639-1650.
11, Aiping Tong, Haiyuan Zhang, Zhengyu Li, Lantu Gou, Zhi Wang, Haiyan Wei, Minghai Tang, Shufang Liang, Lijuan Chen, Canhua Huang, Yuquan Wei. Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol 2008, 61(5):791-802.
12, Su Dan, Deng Hongxing, Zhao Xia, Zhang Xi, Chen Lijuan, Chen Xiancheng, Li Zhengyu, Bai Yu, Wang Yang, Zhong Qian, Yi Tao, Qian Zhiyong, Wei Yuquan. Targeting CD24 for treatment of ovarian cancer by short hairpin RNA. Cytotherapy 2009, 11:642-652.
13, Min Wenjiao, Li Tao, Ma Xiaohong, Li Zhengyu, Yu Tao, Gao Dong, Zhang Bin, Yun Yang, Sun Xueli. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response.Psychopharmacology 2009, 205: 409-417.
14, Bai Yu, Deng Hongxing, Yang Yang, Zhao Xia, Wei Yuquan, Xie Chuan, Li Zhengyu, Chen Xiancheng, Chen Lijuan, Wang Yang, Su Dan, Qian Zhiyong, Zhong Qian, Luo Hong, Yi Tao. VEGF-targeted short hairpin RNA inhibits intraperitoneal ovarian cancer growth in nude mice. Oncology 2009, 77:385-394.
15, Zou Lian, Zhao Xia, Li Zhengyu, Zhou Shengtao, Zhou Lina, Su Dan. Four repetitive partial hydatidiform moles followed by malignant transformation to an invasive mole. Acta Obstet Gynecol Scand 2010, 89:1364-1365.
16, Yang Bing, Gong Changyang, Qian Zhiyong, Zhao Xia, Li Zhengyu, Qi Xiaorong, Zhou Shengtao, Zhong Qian, Luo Feng, Wei Yuquan. Prevention of post-surgical abdominal adhensions by a novel biodegradable thermosensitive PECE hydrogel. BMC Biotechnol 2010, 9:65.
17, Zhou Lina, Du Li, Chen Xiancheng, Li Zhengyu, Wen Yanjun, He Xiang, Wei Yuquan, Zhao Xia, Qian Zhiyong. The antitumor and antime-x-tastatic effects of N-trimethyl chitosan-encapsulated camptothecin on ovarian cancer with minimal side effects. Oncol Rep 2010, 24:941-948.
18, 李征宇赵霞,杨金亮,魏于全。顺铂作用卵巢癌细胞株的蛋白质组学研究。中国科学C辑,2005,35(3):254-261。(MEDLINE收录)
19,李征宇赵霞,魏于全。热休克蛋白对细胞凋亡信号转导途径的调节。中国科学C辑,2004,34(1):6-13。(MEDLINE收录)