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薛志宏

专家 博士生导师

科    室 西部妇幼医学研究院

是否在职 在职

招生方向 其它

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简介

1.职称:研究员、青年千人计划学者

2.学历:博士

3.研究方向:调控心脏发育的新作用因子及其分子作用机制;生心祖细胞的新亚群及其分子标记的分离;心脏谱系细胞体外定向分化方法的探索与优化。

4.邮件:xuez@scu.edu.cn

5.个人经历:

2014.3—2017.7.1博士后,美国麻省理工学院

2014.3—2017.8  2009.1—2014.2博士,美国德克萨斯西南医学中心—达拉斯分校

6.代表性论文:

(1)Xue, Z., Ye, Q., Anson, S.R., Yang, J., Xiao, G., Kowbel, D., Glass, N.L., Crosthwaite, S.K., and Liu, Y. (2014). Transcriptional interference by antisense RNA is required for circadian clock function. Nature 514, 650-653. (IF=38.1)

(2)Xue, Z., Hennelly, S., Doyle, B., Gulati, A.A., Novikova, I.V., Sanbonmatsu, K.Y., and Boyer, L.A. (2016). A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage. Mol Cell 64, 37-50. (Highlighted by Mol Cell, Nature Chemical Biology, and Science Signaling) (IF=14.0)

(3)Xue, Z., Yuan, H., Guo, J., and Liu, Y. (2012). Reconstitution of an Argonaute-dependent small RNA biogenesis pathway reveals a handover mechanism involving the RNA exosome and the exonuclease QIP. Mol Cell 46, 299-310. (IF=14.0)

(4)Lee, H.C.*, Li, L.*, Gu, W.*, Xue, Z., Crosthwaite, S.K., Pertsemlidis, A., Lewis, Z.A., Freitag, M., Selker, E.U., Mello, C.C., Liu, Y. (2010). Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi. Mol Cell 38, 803-814. (IF=14.0)

(5)Zhang, Z.*, Chang, S.S.*, Zhang, Z., Xue, Z., Zhang, H., Li, S., and Liu, Y. (2013). Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway. Genes Dev 27, 145-150. (IF=10.0)

(6)Yang, Q., Li, L., Xue, Z., Ye, Q., Zhang, L., Li, S., and Liu, Y. (2013). Transcription of the major Neurospora crassa microRNA-like small RNAs relies on RNA polymerase III. PLoS Genet 9, e1003227. (IF=6.7)

(7)Dang, Y., Li, L., Guo, W., Xue, Z., and Liu, Y. (2013). Convergent transcription induces dynamic DNA methylation at disiRNA loci. PLoS Genet 9, e1003761. (IF=6.7)

(8)Dang, Y., Yang, Q., Xue, Z., and Liu, Y. (2011). RNA interference in fungi: pathways, functions, and applications. Eukaryot Cell 10, 1148-1155. (IF=3.4)