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张志新

专家 博士生导师

科    室 西部妇幼医学研究院

是否在职 在职

招生方向 母婴医学/应激生物学

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简介

1. 学历:博士

2. Email: Jason_Zhang2011@hotmail.com

3. 研究方向:

B淋巴细胞发育和抗体产生的分子调控

细胞核骨架和B淋巴细胞基因表达以及免疫球蛋白基因重组

自身免疫疾病中诸如红斑狼疮和风湿性关节炎B淋巴细胞的异常功能

B淋巴细胞抗病毒反应

B淋巴瘤和白血病的发病机理

抗肿瘤抗体免疫细胞治疗

4. 教育经历

1985-1989         学士/B.S.            南开大学

1989-1992         硕士/ M.S.          南开大学

1993-1997         博士/ Ph.D.       美国阿拉巴马大学伯明翰分校

1997-2003         博士后                美国阿拉巴马大学伯明翰分校,Max Cooper实验室

5.工作经历

2015-                  四川大学华西第二医院,教授,免疫发育和疾病治疗实验室PI

2014-                  四川大学卓越学者特聘教授

2013-                  终身教授,美国内布拉斯加大学医学中心病理和微生物系

2011-2013         终身副教授,美国内布拉斯加大学医学中心病理和微生物系

2008-2011         副教授,美国内布拉斯加大学医学中心病理和微生物系

2003-2008         助理教授,美国阿拉巴马大学伯明翰分校

6. 代表性论文:

(1)  Rogosch, T, KerzelS, Dey F, Wagner, J-J, Zhang Z,Maier RF, and Zemlin M. IgG4 and IgE transcripts in childhood allergic asthmareflect divergent antigen-driven selection. JImmunol, 193:5801-5808, 2014.

(2)Lange MD, Huang L, Yu Y, Li S, Liao H, Zemlin M, Su K, and Zhang Z*. Accumulation of VHReplacement Products in IgH Genes Derived from Autoimmune Diseases andAnti-Viral Responses in Human, FrontImmunol. 5:345, 2014.

(3)  Zhang B, Liang J, Zhang Z*,Role of biomarkers in management of complications after cardiac surgery. J Cardiovasc Surg (Torino). 55:1-2, 2014.

(4) Huang L, Lange MD, and Zhang Z*. VH replacement footprintanalyser-I (VHRFA-I), a Java based computer program for analyses ofimmunoglobulin heavy chain genes and potential VH replacementproducts in human and mouse. Front.Immunol. 5:40, 2014.

(5)  Shi G, Zhang J, Zhang Z, Zhang X, Systemic autoimmunediseases. Clin Dev Immunol, 2013:728574, 2013

(6)Li S, Yu Y, Yue Y, Zhang Z,Su K, Microbial infection and rheumatoid arthritis. J Clin Cell Immunol, 4:174,2013.

(7)  Li S, Yu Y, Koehn CD, Zhang Z,Su K, Galectins in the Pathogenesis of Rheumatoid Arthritis. J Clin Cell Immunol, 4:164, 2013.

(8) Liu J, Xie W, Lange M, Hong SY, SuK, and Zhang Z*, Internalization of B cell receptors (BCRs) in human EU12 muHC+immature B cells specifically alters downstream signaling events. BioMed Res International, 2013:807240, 2013.

(9) Huang X, Huang L, Peng H, Guru A, Xue W, Hong SY, Liu M, Sharma S,Fu K, Caprez AP, Swanson DR, Zhang Z,and Ding S-H, ISPTM: An iterative search algorithm for systematicidentification of post-translational modifications from complex proteomemixtures. J Proteome Res, 12:3831−3842, 2013.

(10) Liu J, Lange M, Hong SY, Xie W, Huang L, Ehrhardt G, Burrows PD, Su K,Carter R, and Zhang Z*,Regulation of VH replacement by B cell receptor (BCR)-mediatedsignaling in human immature B cells. J.Immunol. 190:5559-5566, 2013.

(11)Huang L, Lange MD, Yu Y, LiS, Su K, and Zhang Z*. Contributionof VH replacement products in mouse antibody repertoire. PLoSOne, 8:e57877, 2013.

(12) Liao H, Run F, LiuJ, Lange M, Su K, and Zhang Z*, Contribution of VH replacement products to the generation ofanti-HIV antibodies. Clinical Immunol, 146:46-55,2013.

(13) He T, Hong SY, Huang L, Xue W, Yu Z, Kwon H,Kirk M, Ding SJ, Su K, Zhang Z*.Histoneacetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediatedtranscriptional activity. J Biol Chem.286:14137-14145. 2011.